YES!!! You will want to! When the #2 Nail Base & Top Gel brush touches the dip powder or activator, it can make the brush become gooey or hard. It’s good measure after doing a few nails to just simply switch the brush out of your Brush Cleaner with the dirty brush, then let it soak for a bit while you do a few more nails. This will keep your brushes clean for a smooth application.